Retinopathy of Prematurity




Differential Diagnoses


  1. Treatment is initiated when there is ROP in zone I or II, with five contiguous or eight cumulative clock hours of stage 3, and with plus disease where severe visual loss occurs approximately 50% of the time. (Threshold Retinopathy)

Instructions for Follow-Up


  1. 90% of Stage 1 and Stage 2 disease regresses spontaneously
  2. Approximately 50% of Stage 3 disease can regress spontaneously
  3. Prognosis for stage 4 and 5 disease is poor, with a high incidence of visual problems and retinal detachment

Prevention & Screening

  1. At least one, possibly two, funduscopic exams beginning at 4-6 week of life