Paraneoplastic Syndromes


HORMONE/AGENT EFFECT NEOPLASM
1,25-(OH)2 D3 (calcitriol) Hypercalcemia Hodgkin lymphoma, some non-Hodgkin lymphomas
ACTH Cushing syndrome Small cell lung carcinoma
ADH SIADH Small cell lung carcinoma and intracranial neoplasms
Antibodies against presynaptic Ca2 channels at NMJ Lambert-Eaton myasthenic syndrome (muscle
weakness)
Small cell lung carcinoma
PTHrP Hypercalcemia Squamous cell lung carcinoma, renal cell carcinoma, breast cancer
Erythropoietin Polycythemia Renal cell carcinoma, thymoma, hemangioblastoma, hepatocellular carcinoma, leiomyoma, pheochromocytoma