TTP


Diagnosis

Pathophysiology

Treatment

  1. Steroids: methylprednisolone 1mg/kg/d IV
  2. Plasmapheresis/Plasma exchange transfusion (a process in which the liquid in the blood, or plasma, is separated from the cells. In sick people, plasma can contain antibodies that attack the immune system. A machine removes the affected plasma and replaces it with good plasma, or a plasma substitute) coupled with FFP infusion (EMERGENT!):
  3. ? Plasma transfusion if plasma exchange is not available
  4. Avoid platelet transfusions unless uncontrolled hemorrhage (can aggravate thrombosis)
  5. Antiplatelet agents (ASA) controversial
  6. Splenectomy = refractory to Rx or relapsing
  7. Monitor closely: relapses in up to 40%

Disposition

  1. ICU admission