Thrombocytopenia


Pathophysiology 

  1. Marrow infiltration (tumor or infection)
  2. Aplastic anemia
  3. Drugs-thiazides, estrogens, ethanol, chemo agents, heparin, protamine
  4. Radiation
  5. B12 and/or folate deficiency
  6. ITP
  7. TTP
  8. HUS
  9. DIC
  10. Viral infections: HIV, mumps, varicella, EBV
  11. Splenic sequestration-hyperplenism, hypothermia
  12. Excessive hemorrhage
  13. Hemodialysis
  14. Bypass
  15. Pseudothrombocytopenia: lab phenomenon

Diagnosis

Treatment

  1. Platelet Count:
  2. Platelet count should be maintained at 50,000/mcL [50x10^9/L] or greater if pt undergoing major surgery or having significant ongoing bleeding
  3. Transfusion
  4. For further general information on platelets.

 

Volume:

50 mL/unit

Composition:

1 unit represents platelets removed from 1 unit of blood

Indications:

Platelet count < 20,000 in non-bleeding patient

Platelet count < 50,000 before surgery or with active bleeding

Dosage:

1 unit should increased platelet count by 6,000
Adult: 6-10 units
Peds: 5 mL/kg