Indication for Hospitalization:
- Bilirubin > 20
- Age > 45
- Percutaneous, parenteral, or sexual transmission
- 50% develop chronic cirrhosis, cancer
- No effective vaccine
- HCV genotype, PCR
- HBV surface Ab, Surface Ag, HBV Core Ab.
- HAV total Ab
- R/O autoimmune hepatitis or primary sclerosing Cholangitis:
- Anti-smooth muscle Ab
- Anti-mitochondrial Ab
- CMP, INR for MELD score
- Iron panel, TIBC, Ferritin
- RUQ US
- AFP level
|Elisa anti-HCV Ab
|(-) but suspicious (↑ AST,ALT)
HCV RNA PCR
- HCV RNA PCR
- Viral Genotype
- Baseline testing for anti-HCV and ALT activity
- Follow-up testing at 4-6 months for anti-HCV and ALT
activity OR HCV RNA at 4-6 weeks
- Exposed individuals should not donate blood, plasma, organs,
tissue, or semen
- Exposed person does not need to modify sexual practices or
refrain from pregnancy or discontinue breast feeding
- When HCV infection is confirmed early, the person should be
referred for medical management to a specialist in this area
- IG and anti-viral agents are not recommended
HCV in pregnancy
- HCV Viral load
- Viral Genotype
- Expectant management like any other pregnancy.
- Normal Vaginal delivery OK
- AVOID scalp monitor.
- Bath immidiatly
- Screen at age 1 yr old.
- Breastfeeding OK (Per CDC)
- Nephritic syndrome, IV
drug user, Low Complement level.
- (+) renal dysfunction = Only INF-Alpha,
renal dysfunction= INF-Alpha + Ribavirin.
ITE 2014 Q81.
- Lichen planus is an idiopathic inflammatory disease
affecting the skin and oral mucosa.
- The characteristic violaceous, polygonal papules may be
- There is a significant association between lichen
planus and hepatitis C virus infection
A 53-year-old white female with chronic hepatitis C is concerned about ulcers in her mouth. She
is not currently receiving therapy. Your examination reveals several ulcers involving the buccal
mucosa. The patient also points out a number of pruritic, reddish-purple plaques on her wrists,
ankles, and back. Laboratory studies are within normal limits except for mildly elevated
Which one of the following is the most likely diagnosis?
A) Behçet’s syndrome
B) Lichen planus
C) Aphthous stomatitis
D) Herpetic stomatitis
E) HIV infection
- Lichen planus is an idiopathic inflammatory disease affecting
the skin and oral mucosa. The characteristic violaceous, polygonal
papules may be intensely itchy. There is a significant association
between lichen planus and hepatitis C virus infection.
Ref: Le Cleach L, Chosidow O: Lichen planus. N Engl J Med