Frontotemporal Dementia

Case Discussion
A 64-yo man is brought in by his family after exposing himself in public. He has been urinating in the kitchen sink and refuses to bathe. His MMSE is 26/30. He has some wording finding difficulties.

The most likely diagnosis is?

A. Alzheimer’s disease
B. Frontotemporal dementia
C. Diffuse Lewy body dementia
D. Vascular dementia
E. Creutzfeldt-Jakob disease

  • Pick’s disease and non-specific degeneration of frontal lobes; corticobasal dementia, progressive supranuclear palsy (“Parkinson plus” syndromes)
  • Behavioral problems early (disinhibition and/or profound apathy) plus aphasia
  • Memory and visuospatial problems later
  • May or may not have speech difficulty.

Dementia Alzheimer's Dementia Predominant memory loss
Minor Neuro-cognitive Disorder  
“Pseudodementia” (Dementia Syndrome of Depression)  
Vascular Dementia  
Diffuse Lewy Body Dementia Predominant memory loss
Frontotemporal Dementia Predominant Behavior/personality change
Normal Pressure Hydrocephalus  
Creutzfeldt-Jakob Disease