- Embryotoxic, not teratogenic
– Infection 1st trimester = Miscarriage
– Peaks early 2nd trimester = fetal anemia, hydrops fetalis, and
- Fetus at greatest risk 3-6 weeks after maternal infection
– Screening: Maternal IgG and IgM
- Fetal monitoring: Weekly U/S and middle cerebral artery
– If hydrops and anemia are present = RBC transfusion may be needed.