Lab values in bone disorders

also see Hyperparathyroidism
DISORDERS Serum Ca Vit D PO4 ALP PTH Comments
Osteoporosis -- -- -- -- -- bone mass
Osteopetrosis - / -- -- -- -- Dense, brittle bones. Ca in severe, malignant disease
Paget disease -- -- -- -- Abnormal “mosaic” bone architecture
Osteomalacia/rickets   Soft bones
Hypervitaminosis D -- Caused by over-supplementation or granulomatous disease (e.g., sarcoidosis)
Osteitis fibrosa cystica           “Brown tumors” due to fibrous replacement of bone, subperiosteal thinning
Primary Hyperparathyroidism - /↓ Idiopathic or parathyroid hyperplasia, adenoma, carcinoma
Secondary Hyperparathyroidism Often as compensation for ESRD (PO4 excretion and production of activated vitamin D)
Tertiary Hyperparathyroidism       ↑↑ Squamous Cell Carcinoma (lung) = PTH-Like (PTHrP) = Hypercalcemia = Renal Calculi