Amphetamine Toxicity


Medical indications include attention deficit hyperactivity disorder, narcolepsy, and weight loss.
 
Route of Exposure Onset of Action Peak Action Duration of Action
IV 15-30 s 30 min 10-12 h
Nasal insufflation (snorting) 3-5 min 1-2 h 10-12 h
Inhalation (smoking) 10-30 s 5-10 min 8-12 h
GI 15-20 min 2-3 h 10-12 h

Background

Pathophysiology

Diagnosis

Differential Diagnosis

Treatment

  1. Acute toxicity
  2. Chronic amphetamine use

Disposition

  1. Admit
  2. Discharge

Follow-UP

  1. Psychosocial intervention and close monitoring to reduce recurrence
  2. Frequent urine toxicology screening
  3. Drug treatment program enrollment
  4. Refer to specialist to address any end organ damage
  5. Withdrawal Syndrome

Prognosis

Prevention