Monomine Oxidase Inhibitors Toxicity


Rarely used today as first-line agent for depression due to narrow therapeutic window and drug interactionss
Examples include:

MECHANISM/TOXICITY

SYMPTOMS/EXAM

DIFFERENTIAL

DIAGNOSIS

ED CARE & DISPOSITION

Supportive care & Management of complications.
  1. IV access, Cardiac monitoring.
  2. Give all pts activated charcoal. Gastric lavage recommended if it can be performed within 1 hr of ingestion.
  3. Hypertension:
  4. Nitroglycerine for anginal chest pain & signs of myocardial ischemia.
  5. Hypotension:
  6. Ventricular Dysrhythmia:
  7. Bradycardia:
  8. Seizure:
  9. Hyperthermia:
  10. Avoid:
  11. Pt who have ingested > 1mg/kg require ICU admission. Those who ingested less can be admitted to monitored bed. Observe asymptomatic pt for 24 hr.

COMPLICATIONS