Other Anti-hypertensive Toxicity


Table below lists other hypertensive agents that may present with acute toxicity in overdose. These drugs usually will cause symptoms, but they are rarely as life-threatening as a single drug ingestion.

DIAGNOSIS

TREATMENT

Toxicity From Hypertensive Agents
DRUG MECHANISM/TOXICITY SYMPTOMS/EXAM
Hydralazine Direct acting vasodilator Hypotension
Tachycardia
Hypokalemia
Minoxidil Inhibits Ca++ uptake into cells
→ vasodilation
Hypotension
Tachycardia
Methyldopa Metabolite stimulates central
alpha-receptors → ↓ sympathetic
output.
Hypotension
Miosis
Sedation
Resp. Depression
Guanethidine
Guanadrel
Decreases norepinephrine release from nerve terminals Hypotension
Doxazocin
Parazosin
Terazosin
Selective alpha1-receptor blocker → ↓ PVR Hypotension
Tachycardia
Dizziness/syncope