SNRI Toxicity

Clinical Features


There are no established guidelines for treating SNRI overdose
  1. Initiate IV access & cardiac monitoring
  2. Single-dose activated charcoal is appropriate in most cases. Gastric lavage may be beneficial with early presentation after large ingestion.
  3. Benzodiazepine are the anticonvulsants of choice.
  4. Treat hypotension w/ IV Fluids & a direct-acting Alpha-Agonist


  1. All pts require at least 6 hr observation, longer for those ingesting extended-release preparations.
  2. Admit symptomatic pts to monitored bed.