Sedative-Hypnotic Withdrawal


Pathophysiology
  1. Chronic use of sedative-hypnotics decr. GABA, down regulates inhibitory receptors
  2. Risk factors for toxicity

Diagnosis

  1. Symptoms
  2. PE
  3. Diagnostic testing

Treatment

  1. ABCs, IV, O2, monitor
  2. Substitute drugs of long duration of action (benzos or phenobarbital) for a few days & gradually wean after 2-3 wks
  3. Hyperactivity, seizures (see Alcohol Withdrawal)
  4. Thiamine 100 mg qD, glucose, MVI

Disposition

  1. Admit
  2. Discharge
  3. Drug counseling