Trazodone Toxicity


Clinical Features

ED CARE

Supportive care is generally sufficient in isolated overdose.
  1. Initiate cardiac rhythm monitoring & obtain a 12-Lead ECG
  2. Single-dose activated charcoal is recommended. Gastric lavage followed by activated charcoal may be beneficial for ingestion > 2 g if early after ingestion.
  3. Hypotension:
  4. Torsades de pointes: Magnesium Sulfate 2g IV

Disposition

  1. Discharge pt who remain asymptomatic for at least 6 ht, with psychiatric evaluation as indicated.
  2. Admit those with neurologic and/or cardiac symptoms for > 6 hrs after ingestion to a monitored bed.