Wellbutrin Toxicity

Clinical Features


Seizures should be anticipated. Cardio-toxicity unlikely in isolated overdose.
  1. Start peripheral IV line & initiate cardiac rhythm monitoring.
  2. GI Decontamination if done within 1 hr of ingestion. Consider whole-bowel irrigation in overdoses of sustained-release products.
  3. Treat seizures with benzodiazepines, followed by phenobarbital.


  1. Observe
  2. Admit those with seizures, persistent tachycardia, or lethargy.